Letter to the Editor: Classical Hodgkin Lymphoma and the Measles Virus
نویسنده
چکیده
An association between measles virus (MV) proteins and RNA and classical Hodgkin lymphoma (cHL) was first demonstrated by immunohistochemistry, RT-PCR and in situ hybridization, in 2004 [1]. We used several commercial and experimental anti-MV antibodies. Total RNA was extracted from all available snap-frozen tissue and from a few FFPE tissues out of a random cohort of 154 cHL untreated patients. Of the 154 biopsies, 82 (54%) were positive for at least two MV antigens. By Southern blot, 4 of 15 hemagglutinin (HA) MVRNAs, as well as 2 of 16 nucleoprotein (NP) MV-RNAs were positive. In situ hybridization showed that 2 of 7 HA and 8 of 21 NP-MV-RNAs were positive [1].
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تاریخ انتشار 2016